Choline oxidaseA (codA) gene plays a role in glycine betain, which induce stress tolerance ability in Arthrobacter globiformis, formation. In previous study, codA gene transformed cyanobacterium and plants exhibited stress tolerance ability,as well. In this study, codA was transformed into yeast (Saccharomyces cerevisiae) through pTB326 and pYES2 vector. Furthermore thermotolerance ability is to be investigated.